Success Rates 2013

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Is there anything I need to do after the embryo transfer to help become pregnant?

There will be specific guidelines handed to you after your embryo transfer. In this document, you will find information on what to do and what not to do to help the process. Once the embryo transfer has been performed, there is not much to do to assist with conception. However, there are things that can be done in order not to jeopardize the process and to make sure you don’t do things that can negatively impact embryo’s ability to implant. These have to do with your diet and physical activities that require strength. Otherwise, you will be able to continue your daily chores without any interruption, but will simply take it down a notch.

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How soon after the embryo transfer will I know whether I am pregnant or not?

A beta hCG test will be administered 12 days after your embryo transfer to detect hCG hormone in blood. This is a specific hormone released immediately after pregnancy occurs. This is the soonest that pregnancy can be detected. We do not recommend using a home pregnancy test as they are not very accurate too early into your pregnancy and they may not be able to detect anything until 15/16 days after your embryo transfer. Therefore, a home pregnancy test done too early is likely to indicate a negative result as it is unable to detect pregnancy and will cause disappointment. Please schedule you beta hCG test 12 days after your embryo transfer at your local doctor for most accurate results.

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Egg Retrieval and Embryo Transfer

The decision regarding the timing of the third injectable medication (Ovidrel, or HCG) is determined by a combination of events that include size and number of the leading (largest) ovarian follicles observed on ultrasound and blood level of ovarian hormone/s.  The timing of the Ovidrel/HCG injections is critically important as your egg retrieval procedure is scheduled at a specified hour following this injection.You will be provided with clear instructions regarding the timing for this injection. You must not eat or drink anything past midnight the night before the egg retrieval.Male Partners: The day your partner is instructed to take the Ovidrel or HCG injection, it is recommended that you ejaculate in order to have a fresh sample with healthier sperm available on the day of egg retrieval (unless you are instructed otherwise).

Egg Retrieval

Please note that your partner must accompany you to provide his sperm specimen at the time of your scheduled egg retrieval.  You will meet with our expert IVF nursing staff on your arrival for the scheduled egg retrieval procedure. Please feel free to mention any concerns or questions you may have before the procedure. After your paperwork is reviewed, including consents, and after all your questions are addressed, an IV will be placed in one of your arm veins for administration of medications during the egg retrieval procedure. You will then be chaperoned to our procedure room for the egg retrieval that takes approximately 30 minutes (depending on the individual patient’s ovarian response – as retrieval of eggs from a larger number of ovarian follicles may take a few extra minutes).The egg retrieval involves a transvaginal ultrasound almost identical to the scans performed during the monitoring process. We use a combination of intravenous sedatives and local anesthetic to keep you comfortable during the egg retrieval procedure. A needle guide is attached to the side of the vaginal ultrasound probe, to accommodate the egg retrieval needle; under ultrasound guidance, the needle is passed along the ultrasound guide through the wall of the vagina into the ovary and the fluid within the visible follicles is aspirated; this fluid contains the egg surrounded by cells. The aspirated fluid is passed on to the embryologist who identifies the egg from each aspirate.

Embryo Transfer Embryo transfer is a simple, painless procedure that is performed under abdominal ultrasound guidance.

When to transfer embryos:The timing of embryo transfer is dependent on the number and quality of available embryos and on individual patient related circumstances. Embryos are almost exclusively transferred on Day 3 (cleaving embryos) or Day 5 (blastocyst stage embryos).

How does one decide on the number of embryos to transfer:The decision on how many embryos to transfer is based on a number of factors including the age of the female partner, her prior reproductive history and health profile (placing in perspective risks of multiple pregnancy for the woman), the number and quality of the available embryos, and couple’s acceptability of selective reduction in the event of a high order multiple pregnancy (more than twins) resulting from embryo transfer. Couples are encouraged to discuss these considerations and communicate their concerns and preferences at any and all times through the IVF process. Your infertility specialist will review your embryo status including fertilization, embryo development and the quality of embryos on the day of embryo transfer. The embryology team and your infertility specialist will identify the most optimal of the embryos available for transfer. 

Procedure of Embryo Transfer:You will be asked to come in with a full bladder, change into a procedure gown and will be taken to the procedure room. For patients who have previously undergone an insemination, embryo transfer is a similar procedure. With you lying down, one of our trained staff members will perform an abdominal ultrasound scan (which requires a full bladder to allow optimal visualization), while your fertility specialist gently cleanses the cervix with the fluid your embryo/s are bathed in. The pre-selected embryo/s will be “loaded” into an embryo transfer catheter; the catheter is passed on to the fertility specialist who performs a trans-cervical embryo transfer under the guidance of abdominal ultrasound. For the majority, the procedure of embryo transfer takes just a few minutes. You should not feel any discomfort during the embryo transfer procedure, and will be asked to remain reclining for an additional 15 minutes.

Source : http://goo.gl/JrBjaz

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Infertility and IVF

At North Cyprus IVF Clinic, a thorough investigation is called for when making an assessment of your treatment options. It is important that the cause of infertility is mostly known when planning for treatment. 

When natural conception methods fail to produce pregnancy, IVF becomes an option. In vitro fertilization (IVF) is a process by which egg cells are fertilized by sperm outside the womb, in vitro. IVF is a major treatment in infertility when other methods of assisted reproductive technology have failed. The process involves hormonally controlling the ovulatory process, removing ova (eggs) from the woman's ovaries and letting sperm fertilize them in a fluid medium. The fertilized egg (zygote) is then transferred to the patient's uterus with the intent to establish a successful pregnancy. The first "test tube baby", Louise Brown, was born in 1978. Initially IVF was developed to overcome infertility due to problems of the fallopian tube, but it turned out that it was successful in many other infertility situations as well. The introduction of intracytoplasmic sperm injection (ICSI) addresses the problem of male infertility to a large extent. (Male infertility consists of failure to produce sperm.)

For IVF to be successful it may be easier to say that it requires healthy ova, sperm that can fertilize, and a uterus that can maintain a pregnancy. At North Cyprus IVF, before starting to plan your treatment, we make sure all of these conditions are met.

IVF can be used for females who have already gone through menopause. The donated oocyte from a healthy young woman can be fertilized in a crucible. If the fertilization is successful, the zygote will be transferred into the uterus, within which it will develop into an embryo.

Treatment cycles are typically started on the third day of menstruation and consist of a regimen of fertility medications to stimulate the development of multiple follicles of the ovaries. In most patients injectable gonadotropins (usually FSH analogues) are used under close monitoring. Such monitoring frequently checks the estradiol level and, by means of gynecologic ultrasonography, follicular growth. Typically approximately 10 days of injections will be necessary. Spontaneous ovulation during the cycle is typically prevented by the use of GnRH agonists or GnRH antagonists, which block the natural surge of luteinizing hormone (LH).

When follicular maturation is judged to be adequate, human chorionic gonadotropin (hCG) is given. This agent, which acts as an analogue of luteinizing hormone, would cause ovulation about 42 hours after injection, but a retrieval procedure takes place just prior to that, in order to recover the egg cells from the ovary. The eggs are retrieved from the patient using a transvaginal technique involving an ultrasound-guided needle piercing the vaginal wall to reach the ovaries. Through this needle follicles can be aspirated, and the follicular fluid is handed to the IVF laboratory to identify ova. It is common to remove between ten and thirty eggs. The retrieval procedure takes about 20 minutes and is usually done under conscious sedation or general anesthesia.

In the laboratory, the identified eggs are stripped of surrounding cells and prepared for fertilization. In the meantime, semen is prepared for fertilization by removing inactive cells and seminal fluid. If semen is being provided by a sperm donor, it will usually have been prepared for treatment before being frozen and quarantined, and it will be thawed ready for use. The sperm and the egg are incubated together at a ratio of about 75,000:1 in the culture media for about 18 hours. In most cases, the egg will be fertilized by that time and the fertilized egg will show two pronuclei. In certain situations, such as low sperm count or motility, a single sperm may be injected directly into the egg using intracytoplasmic sperm injection (ICSI). The fertilized egg is passed to a special growth medium and left for about 72 hours until the egg consists of eight cells.

Egg Quality

Many women do not realize the importance of egg quality when dealing with infertility. It is a factor that can effect the results and outcome of the IVF process.

The finite reserve of eggs in a woman are released during ovulation and can be fertilized to produce a child. Unfortunately, having a large number of eggs does not  mean that you will fall pregnant. The quality of those eggs are more important in the eventual development of an embryo.

In order for an embryo to develop,  the eggs need to have the correct chromosomes and the ability to fertilize with the sperm.  If the eggs do not have the proper chromosomes, it is not possible to achieve a successful pregnancy.

The female eggs contain mitochondria which is the energy in the eggs that allow it to split for fertilization. With age, the mitochondria produce less energy and stop the egg from dividing.

Apart from age, factors such as smoking, radiation therapy, chemotherapy and endometriosis can also have an effect on egg quality.

FSH testing is generally used to measure the quality of the eggs and a high level might indicate poor egg quality.

Please contact us for further information.

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Patient Review - North Cyprus IVF Center

Here is yet another review from one of our patients:


Hi,

I am so happy to let you know that we had our pregnancy blood test result yesterday and it's a positive!
We are over the moon, yet still cautious and hope the next 10 weeks will go smoothly.

I just wanted to double check that I will be taking 2 x Progynova twice a day and Crinone gel twice a day, plus the Pregnacare and junior aspirin once a day until we are the 12 week mark. Once we get past the first trimester do we just stop the Progynova and Crinone or do a gradual wind down? And carry on with the Pregnacare and junior aspirin throughout my pregnancy?  

If you can also pass on our heartfelt thanks to Drs Savas and Idil, as well as yourself, Angie and the nurses- everyone was so fantastic during our time there and we also enjoyed visiting your country.
Please let me know about the meds. 

With all our best wishes and gratitude.

L & B, United Kingdom

Please contact us for further information. 


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Tips for IVF Success

Even though each IVF treatment is different in itself, there are a number of measures that can be taken in order to maximize your chances of success. In some cases, things that might sound small could make a world of difference in IVF treatment. So let’s be on the safe side and do our part:

1- INITIAL SCAN: Have an ultrasound scan at your gynecologist’s office. This is to make sure there are no fibroids, polyps or free fluids in the uterus that could jeopardize your chances of success. Also, women who are not undergoing egg donor IVF treatment should make sure there are no cysts in the ovaries that could potentially affect their egg count/quality.

2- INVESTIGATION: If you have previously had repeated miscarriages (with or without IVF), it makes sense to investigate the cause. In most cases where women have repeated miscarriages, there is a genetic reason behind it. Some gene mutations affect your blood circulation and cause you to have a miscarriage (especially up to 12 weeks). These genetic tests include testing for mutations in MTHFR C677T, MTHFR A1298C, Factor V Leiden (G1691A), Factor II (G20210A), and PAI I 4G/5G. Similarly, women with repeated IVF failures should seek further investigation.

3- VITAMINS: It is important that your take essential vitamins and nutrients prior to and during pregnancy. A supplement such as “pregnacare” includes Folic Acid, B6, B12 and Zinc supplements, which are proven to reduce the likelihood of a miscarriage and support healthy development of your baby. It makes sense to start using such a supplement at least a few weeks prior to your embryo transfer stage. Vitamin C taken at certain doses has also proved effective in increasing egg quality according to various clinical studies.

4- HORMONE TESTING: For women undergoing IVF treatment using their own eggs, it is important that certain hormone tests are done prior to using any IVF medication. These hormone tests include:
FSH, LH, Estradiol Prolactine and TSH. For women over 35, AMH test will also be an important consideration. Based on these hormone test results, we will be able to assess your ovarian reserves and egg quality. Also, it these results will be important in identifying your treatment protocol and the dose of medication that needs to be administered.

5- IVF FAILURES: For patients who have had several failed IVF attempts, with no history of pregnancy, it makes sense to have an endometrial biopsy around days 18-21 of menstrual period. An endometrial biopsy will tell whether there is any condition that might prevent implantation and a successful pregnancy. There are also other infections that need to be checked for in this case.

6- INFECTIOUS DISEASES: Prior to embryo transfer, it is vital that certain infectious disease tests are done on both parents. The purpose of these tests is to make sure the newborn does not receive any infection from his/her parents. Some of these test are routine tests, which most of you do not have, such as Anti-HIV, Anti-HCV. These can be done at our clinic prior to embryo transfer. However, some other test results, such ac CMV IgG and Chlamidia might require the use of antibiotics for a certain amount of time prior to emrbyo transfer, therefore, it is important for the female patient to have tested for CMV IgG and Chlamidia once the IVF decision has been made.

7- AVOID STRESS: One of the biggest enemies of IVF treatment is stress. Avoid stress as much as you can when going through IVF treatment. You can take up yoga classes, or join the gym or start a book club, anything that will help you avoid stress will add a couple of percentages to your chances of success.




www.donasyon.net 
www.lowcostivf.net 
www.northcyprusivf.com 
www.gender-selection-ivf.co.uk 
www.egg-donor-ivf.co.uk

7 Tips for Success in IVF Treatment

Even though each IVF treatment is different in itself, there are a number of measures that can be taken in order to maximize your chances of success. In some cases, things that might sound small could make a world of difference in IVF treatment. So let’s be on the safe side and do our part:

1- INITIAL SCAN: Have an ultrasound scan at your gynecologist’s office. This is to make sure there are no fibroids or polyps in the uterus that could jeopardize your chances of success. Also, women who are not undergoing egg donor IVF treatment should make sure there are no cysts in the ovaries that could potentially affect their egg count/quality.

2- INVESTIGATION: If you have previously had a number of miscarriages (with or without IVF), it makes sense to investigate the cause. In most cases where women have repeated miscarriages, there is a genetic reason behind it. Some gene mutations affect your blood circulation and cause you to have a miscarriage (especially up to 12 weeks). These genetic tests include testing for mutations in MTHFR C677T, MTHFR A1298C, Factor V Leiden (G1691A), Factor II (G20210A), and PAI I 4G/5G.

3- VITAMINS: It is important that your take essential vitamins and nutrients prior to and during pregnancy. A supplement such as “pregnacare” includes Folic Acid, B6, B12 and Zinc supplements, which are proven to reduce the likelihood of a miscarriage and support healthy development of your baby. It makes sense to start using such a supplement at least a few feeks prior to your embryo transfer stage.

4- HORMONE TESTING: For women undergoing IVF treatment using their own eggs, it is important that certain hormone tests are done prior to using any IVF medication. These hormone tests include:

FSH, LH, Estradiol and Prolactine. Based on these hormone test results, we will be able to assess your ovarian reserves and egg quality. Also, it these results will be important in identifying your treatment protocol and the dose of medication that needs to be administered.

5- IVF FAILURES: For patients who have had several failed IVF attempts, with no history of pregnancy, it makes sense to have an endometrial biopsy around days 18-21 of menstrual period. An endometrial biopsy will tell whether there is any condition that might prevent implantation and a successful pregnancy. There are also other infections that need to be checked for in this case.

6- INFECTIOUS DISEASES: Prior to embryo transfer, it is vital that certain infectious disease tests are done on both parents. The purpose of these tests is to make sure the newborn does not receive any infection from his/her parents. Some of these test are routine tests, which most of you do not have, such as Anti-HIV, Anti-HCV. These can be done at our clinic prior to embryo transfer. However, some other test results, such ac CMV IgG and Chlamidia might require the use of antibiotics for a certain amount of time prior to emrbyo transfer, therefore, it is important for the female patient to have tested for CMV IgG and Chlamidia once the IVF decision has been made.

7- AVOID STRESS: One of the biggest enemies of IVF treatment is stress. Avoid stress as much as you can when going through IVF treatment. You can take up yoga classes, or join the gym or start a book club, anything that will help you avoid stress will add a couple of percentages to your chances of success.

www.donasyon.net 
www.lowcostivf.net 
www.northcyprusivf.com 
www.gender-selection-ivf.co.uk 
www.egg-donor-ivf.co.uk

2011's Last Bundles of Joy!