Defining Infertility

We can simply define Infertility as "inability to conceive" or "inability to carry pregnancy to a full-term". Close to ten percent of the western population, those between the ages of 15-44, having infertility problems. Although many assume infertility is female problem, female and male infertility have almost the same level of prevalence within the society.

While primary infertility definition includes couples who have been trying to get pregnant for the last year but incapable to do so, secondary infertility involves couples who have previously conceived but are not able to do so any more. Some factors that may cause secondary infertility are ; age, premature menopause, exposure to radiation therapy, chemotherapy, surgical complications, bad diet and more.

Initial fertility testing differ for each couple depending on the factors such as; time they have been trying to conceive, their age, personal history of fertility treatments, medication protocols used in these treatments, their history with miscarriages and many more.

Please, keep in mind that there is no universal infertility treatment that can be applied each and every patient. Treatments are customized and the one you need cannot be identified until you have been thoroughly checked and tested.

Below, you may find links that will direct you to our pages where you can find detailed information. If you need any more assistance please, feel free to contact us.

Source : http://www.lowcostivf.net/infertility.htm#.U5V-pZSSzM4

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IVF with ICSI at North Cyprus IVF Clinic

The process of In Vitro Fertilization (IVF)  treatment can be simply described as the combination off eggs with sperm in the laboratory environment. As a basic part of this procedure ICSI Is performed so that the best quality sperm is selected and injected into the nucleus of the egg for fertilization. As a result, we catch the opportunity to get potentially the highest quality embryos.

At North Cyprus IVF, IVF treatment is performed through below mentioned five steps;

1st Step: Visiting your gynecologist for pre-testing and a sonogram.

2nd Step: Based on those results, a preliminary work and stimulation of the ovary.

3rd Step: Arriving Cyprus where a final sonogram is executed so that the patient is prepared for the trigger injection.

4th Step: Egg retrieval and in vitro fertilization.

5th Step: Transfer of the embryo transfer.

Our experts as well as IVF specialists at North Cyprus IVF are always more than happy to enlighten you with your IVF treatment options.

Source : http://www.gender-selection-ivf.co.uk/North_Cyprus_IVF_Treatment.html

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How to boost your fertility

Here are 6 tips on how to boost your fertility and chances of success with treatment :

1. Weight Management
2. Eat Right
3. Avoid Drugs, Cigarettes and Alcohol consumption
4. Avoid Stress
5. Have sex!
6. Make sure your partner stays healthy as well!

Please visit http://goo.gl/9BozgX for more information.


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Infertility Testing & Interpreting Test Results

Infertility testing can be very different for different patient groups. For instance, if you have been trying to conceive for some time without success and have had no prior testing and/or investigation done, then the starting point will be the following:

For female partner:

- A sonogram will need to be performed on day 2 or day 3 of her menstrual period. This sonogram will be indicative of the number of antral follicle count (potential eggs for ovulation) and it will give your gynecologist a chance to observe if there are any problems such as cysts in the ovaries, or polyps/fibroids in the uterus/cervix that can possibly interfere with a successful pregnancy process.

- On the very same day, FSH, LH, Estradiol, Prolactin, TSH and AMH hormone tests will need to be administered to make an assessment of the ovarian function. Each of these hormones reflect a different aspect of your fertility. Our specialists at North Cyprus IVF will evaluate your test results and provide a comprehensive feedback on your test results.

For male partner:

- A semen analysis will need to be performed according to WHO 2010 Criteria, as explained in the "Causes of Male Infertility" section.

For couples who have had their initial testing and perhaps have been through a round of fertility treatment will need further investigation. Based on the problems or the lack of problems that may have been observed in initial testing, the following will be investigated:

- A hysterosalpingography for a thorough investigation into the tubes and the uterus

- Infectious disease screening for both partners including Toxoplasmosis, CMV and Chlamydia for the female partner. Sometimes a small infection can cause your body to reject embryo implantation and therefore prevent you from getting pregnant. A short cure of antibiotherapy can sometimes be a solution to a long-suffered infertility problem.

- A karyotype analysis for chromosome testing. If one of the partners suffers from an abnormal karyotype, a genetic problem may be transferred to the offspring. The nature and the severity of the problem will be indicative of what types of measures should be taken.

For couples with repeated IVF failures and/or repeated miscarriages, in addition to the tests mentioned above, female thrombophilia testing will be in order including the following:

MTHFR C677T

MTHFR A1298C

Factor II

Factor V Leiden

PAI 1

Thrombophilia defects can potentially cause blood clotting problems, where blood clots can get into the placental circulation and stop your baby's heart, therefore, resulting in a miscarriage. Thrombophilia defects have also been identified with implantation failures.

This is not a comprehensive list of infertility testing and we may ask for different tests depending on your unique history of infertility.

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What is the age limit for gender selection treatment?

There is no specific age limit for the gender selection treatment, but there is an age limit for IVF treatment. This is in relation to how likely you are to achieve success. If not using a donor, then we will want to make sure your eggs are viable and we have a shot at pregnancy with your own eggs. This is one of the reasons why we ask that patients undergo a series of testing for assessment of their fertility levels prior to proceeding with treatment. Based on these test results, we are able to form an opinion of how likely we are to obtain a good count and quality of eggs in an IVF cycle and how likely these eggs are to produce a healthy pregnancy. We try to emphasize that over the age of 35, the level of fertility tends to decline for female patients and that affects the chances of success with treatment. Over the age of 40, pregnancy rates drop dramatically and unless the patients have a satisfactory level of hormone profile that provides them with some chance of success, we recommend against treatment with own eggs.

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Hormone Testing Before Traveling to Cyprus

The first step in the IVF process would be to have the following hormone tests done on days 2-4 of the menstrual cycle, 1-2 months before you wish to proceed : 

FSH
LH
E2
Prolactin

Once the treatment begins, we will ask that you have 2 follicles tracking scans on cycle day 7 and cycle day 9.

Where can you have these done?

Spain

Marbella:  international@fivmarbella.com

Seville:  international@ginemed.es

Madrid:  info@fivcenter.com

France

Paris : Dr. Celine Davy +33 1 43 80 28 05

Germany 

Berlin : Fertility Center Berlin. Dr. Anette Siemann info@fertilitycenterberlin.de

Netherlands

Amsterdam :  info@geslachtskeuze.nl 

United Kingdom

London : The Birth Company (http://www.thebirthcompany.co.uk/) Dr. Amin Gorgy (http://www.fertility-academy.co.uk/about-us/dr-a-gorgy/)

Midlands : Cherish UK http://cherish-uk.com/

Sweden

Stockholm : Fertilitetslaboratoriet Dr. Gabor Sebestyen +46 08 585 87 504

Please do not hesitate to contact us for further information : northcyprusivfcenter@gmail.com


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Egg Donation (Donor Egg IVF) Questions

1- Who is a good candidate for egg (oocyte) donor IVF?
Women with severely depleted ovarian reserves, women with highly elevated FSH, women in early menopause or with removed ovaries and women who have been subjected to cancer treatment are all candidates for egg donor IVF. In general, egg donation is for women who are not able to produce any eggs that are viable for fertilization.
 

2- Who are your egg donors?
At North Cyprus IVF, our egg donors are predominantly composed of international university students aged between 20-25.
 

3- How are egg donors screened?
Our egg donors undergo a very strict screening process. First, there is a psychological consultation where egg donors' mental status are assessed. If an egg donor is found mentally fit, then there is a background check of family medical history. Once the medical history is assessed, then comes infectious diseases testing, CBC analysis and hormone testing for an assessment of ovarian reserves and egg quality. Only donors who are non-smokers and with healthy BMIs are admitted into our program.
 

4- Do I get to pick my own donor?
Absolutely! You will need to provide us with your menstrual period information, you and your husband's blood types and your physical features so that we can narrow list our potential donors and send you a list of profiles. However, for anonymity purposes, we are not able to share pictures or any contact information.
 

5- What are your success rates for egg donor IVF?
Our overall success rate including all age groups for egg donation in 2011 was 72.8%. For more information on our success rates, please view our success statistics for 2011.

6- How many egg donation cycles do you perform in a given year?
On average, we perform about 350-400 egg donor IVF cycles.

7- What is the cost of egg donor IVF at North Cyprus IVF Clinic?
For most accurate cost information for egg donation including our accommodation packages, please contact us using the contact form.
 

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Resources for Treatment

North Cyprus IVF works with Fertility2u in the U.K. The pharmacy delivers all over the world. You should know that U.K. pharmacies can only accept U.K. prescriptions, therefore, our prescriptions are transcribed into UK prescriptions prior to processing of your order at a minimal cost.

North Cyprus IVF patients can take advantage of low cost scans at one of the baby-bond locations in the U.K. throughout their preliminary medication use prior to the actual physical treatment to be taken place in Cyprus. Choose a location nearest you and book your scan!

Cherish-UK is a private scan and testing center owned and operated by registered nurses. The company offers fertility testing, ultrasound scans and early pregnancy scans. The company also offers package deals at very reasonable costs during your fertility treatment.

Fertility Plus is another pharmacy that services to your door. Fertility plus is an international pharmacy, therefore, it does not need to transcribe our prescriptions into U.K. prescriptions.

Fill Their Arms is a non-profit organization that intends to eliminate the financial hardship that infertile couples experience by empowering family, friends, and community to contribute and provide support.

E-prescribing

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Who Needs an Egg Donor?

Candidate for Egg Donation

Egg donation is the treatment option suitable for the following group of patients:

-Patients with diminished ovarian reserves due to age

-Menopausal patients whose ovulation has stopped.

-Pre-mature menopausal women.

-Patients whose ovarian reserves have been compromised due to chemo or radiotherapy.

-Patients whose ovaries have been removed due to various reasons

-Patients with the risk of passing genetic diseases to her offspring

-Patients experiencing recurrent miscarriages due to chromosomal abnormalities

-Patients with severe endometriosis, whose egg quality have been compromised.

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PGD testing for Genetic Disorders

PGD (Pre-implantation Genetic Diagnosis) technology improves the likelihood of a successful pregnancy and birth for two distinctly different groups of patients. Couples with infertility related to recurrent miscarriage or unsuccessful IVF cycles and couples who are at risk for passing on inherited genetic disease to their offspring.

PGD genetic diagnosis is performed as a part of an In Vitro Fertilization cycle where multiple eggs are produced, retrieved from the ovaries and fertilized with the husband's sperm in the Embryology Laboratory. IVF is necessary to give us access to the embryo in vitro. At their earliest stage of development, one or two cells are removed from each embryo through a procedure called embryo biopsy. These cells are analyzed in the PGD Laboratory to determine which embryos are free of genetic abnormalities. This sophisticated and technologically advanced testing identifies which embryos are free of abnormalities and more able to achieve the patient's goal of a healthy baby. PGD can screen for genetic disorders in chromosomes X, Y, 13, 18 and 21, which make up for about 85% of all major genetic conditions such as Down's syndrome, Tay Sachs and klinefelter's syndrome and many more.

PGD tetsing is also an option when patients require screening for a specific genetic disorder. When the gene that carries the genetic disorder is identified, single gene analysis can be performed in order to screen for the specific disorder. A special PGD probe can be built for this purpose as long as the specific cause of the genetic condition has been identified.

PGD genetic testing is also an option when families would like to select the gender of their baby for family balancing purposes. The embryo biopsy will not only allow us to select embryos that are free of genetic abnormalities, but will also allow us to determine the sex of the embryos. Once PGD is performed, the chance of having a baby of desired sex is very close to 100% once pregnancy is achieved. This process is also known as gender selection (sex selection) IVF.

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Facts About Ovulation

• Ovulation occurs in response to an LH surge which is detectable on a home Ovulation Prediction Kit
• Intercourse should happen as soon as an LH surge is detected
• An egg only lives for 12-24 hours after being released from the ovary but the sperm can live for 3-4 days inside the female after intercourse
• Normally only one egg is released each ovulation, sometimes two eggs are released and this can result in fraternal (non-identical twins)
• If one fertilized egg splits in two, this results in identical twins
• Ovulation can be affected by exercise, stress, illness, drugs or adverse lifestyles
• Some women may experience some light blood spotting around the time ovulation, this is normal
• Implantation of a fertilized egg normally takes place 6-7 days after ovulation
• Each woman is born with millions of immature eggs and the egg supply gradually depletes over time until menopause
• A menstrual period can occur even if ovulation has not occurred
• Ovulation can occur even if a menstrual period has not occurred
• Some women can feel a bit of pain or aching near the ovaries during ovulation called mittelschmerz, which means "middle pain" in German
• If an egg is not fertilized, it will dissolve and is absorbed into the uterine lining
• The only way to know for sure that you have ovulated is to do an ultrasound of the ovary or a luteal phase (day 21) Progesterone blood test. At home, basal body temperature measurements can also predict if and when you have ovulated
• Women with polycystic ovaries usually do not ovulate regularly and may need medication
• Women usually alternate the side on which they ovulate each month
• Symptoms of anovulation (not ovulating) are usually irregular periods or an absence of periods
• Most causes of anovulation can be easily treated
• An ovulation accounts for approximately 30% of all infertility
• One in six couples will have trouble conceiving naturally

Source http://www.facebook.com/pages/ivf/127102485433

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Typical Treatment Calendar for Egg Donation

Your Treatment Calendar:

Date	Use of Medication	Additional Notes
Day 1 of Menstrual Period		Please inform us.
Day 2 of Menstrual Period	1) Progynova tablets (one in the morning, one at night)
Day 3 of Menstrual Period	1) Progynova tablets (one in the morning, one at night)
Day 4 of Menstrual Period	1) Progynova tablets (one in the morning, one at night)
Day 5 of Menstrual Period	1) Progynova tablets (one in the morning, one at night)
Day 6 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night)
Day 7 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night)
Day 8 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night)	First sonogram at your local gynecologist / scan place. We will need to find out about the thickness of endometrium.
Day 9 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night)
Day 10 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night) 2) Doxycycline 100 mg (one in the morning and one at night)
Day 11 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night) 2) Doxycycline 100 mg (one in the morning and one at night)	You should refrain from all sexual activity from this point onward.
Day 12 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night) 2) Doxycycline 100 mg (one in the morning and one at night)
Day 13 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night) 2) Doxycycline 100 mg (one in the morning and one at night)
Day 14 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night) 2) Doxycycline 100 mg (one in the morning and one at night)	Arrival in Cyprus
Day 15 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night) 2) Doxycycline 100 mg (one in the morning and one at night) 3) Progesterone supplements	Expected day of your donor’s egg retrieval. You will have your first consultation with us. Your husband will provide his sample today. Nurses will explain how progesterone supplements will be used.
Day 16 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night) 2) Doxycycline 100 mg (one in the morning and one at night) 3) Progesterone supplements
Day 17 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night) 2) Progesterone supplements
Day 18 of Menstrual Period	1) Progynova tablets (one in the morning, one in the afternoon, one at night) 2) Progesterone supplements	Expected day of embryo transfer. You will be notified of your embryo transfer time via phone the day before.

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Médicaments pour le FIV

Il est nécessaire de prendre certains médicaments pendant le cycle de FIV en vue de préparer le corps pour le traitement. Les instructions pour chaque médicament varient de patient à patient. Nos spécialistes au Nord de Chypre FIV analysera votre dossier de près afin de déterminer quels médicaments à utiliser, ce qui la dose à prendre, quand à administrer les médicaments et combien de temps pour les prendre.

Agonistes de la GnRH - Lucrin, pris comme une injection juste en dessous de la peau et Synarel, un spray nasal, permettent au corps de produire un plus grand nombre d'œufs de haute qualité pendant le cycle de traitement. Ils empêchent également la montée au milieu du cycle hormonal qui peut entraîner l'annulation d'un cycle.

Antagonistes - Antagon et Cetrotide sont des antagonistes de la gonadolibérine (GnRH) et sont utilisés pour prévenir l'ovulation prématurée. Ces médicaments sont administrés par injection et la durée du traitement est généralement de trois ou quatre jours.

Gonadotrophines - Les gonadotrophines sont prises comme des injections sous-cutanées qui fournissent la stimulation des follicules qui contiennent les œufs pendant la phase de stimulation. Gonal F, Bravelle, Follistim, Pergonal et Repronex sont les gonadotrophines les plus couramment utilisés.

hCG - hCGs sont pris comme une injection intramusculaire et sont utilisés pour induire la maturation finale des changements dans les oeufs et les préparer à la récupération. Le hCGs les plus couramment prescrits sont Pregnyl, Ovitrelle Choriomon.

Doxycycline - doxycycline, un antibiotique administré sous forme de pilule, est donnée au partenaire masculin au cours du cycle de stimulation de la femme afin de réduire les faibles niveaux de bactéries qui peuvent être trouvés dans le sperme et qui peut compromettre la performance du sperme au cours d'un cycle de FIV. Il est également accordée à la partenaire féminine pour réduire le risque d'infection après l'aspiration des follicules au moment de la récupération des œufs.

Progestérone - progestérone naturelle peut être pris comme une injection intramusculaire quotidienne commençant deux jours après le prélèvement des ovules et continue jusqu'à ce que le placenta est fait des quantités suffisantes de progestérone. La progestérone peut également être donné sous la forme d'un gel vaginal ou de suppositoires vaginaux ou de comprimés (Prometrium).

Obtention des médicaments et le traitement initial

Au nord de Chypre FIV, nous sommes en mesure de vous envoyer une copie scannée de votre prescription fois que nous voyons certains résultats de tests et d'identifier le bon mode de traitement. Vous pouvez utiliser cette ordonnance à la pharmacie internationale que nous travaillons. La pharmacie est en mesure de livrer dans le monde entier, et ne sont des prix raisonnables. L'adresse de la pharmacie est la suivante:

Site Web: http://www.fertility2u.com

Adresse e-mail: info@fertility2u.com

Personne-ressource: Bushra Sheikh

Avec les médicaments que vous achetez, vous serez en mesure d'avoir votre travail préliminaire au niveau local sous notre supervision et avec les conseils de votre gynécologue local. À la fin de ce processus, il vous sera demandé de se rendre à Chypre pour 7 jours.

L'administration du médicament

Les injections sont tous les sous-cutanée, et sont administrés autour de la zone de ventre. La vidéo suivante fournit des informations sur l'ajustement de mélange et de la dose.

http://www.youtube.com/watch?v=OMklbInsQGk

Après avoir visionné la vidéo sur le lien ci-dessus, s'il vous plaît voir la vidéo sur le lien ci-dessous sur l'injection:

http://www.youtube.com/watch?v=AHEyyB0IKNY

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Egg Donation Program

Egg Donation IVF is the treatment method for women who do not have healthy eggs for conception. The following list indicates women who are ideal candidates for egg donor IVF treatment at North Cyprus IVF clinic:

- Women who are going through premature menopause
- Women who have had their ovaries removed and therefore do not produce eggs
- Women who have undergone cancer treatment and have damaged ovaries
- Women who were born without functioning ovaries (Turner's syndrome)
- Women with poor ovartian reserves
- Women with hereditary genetic disorders
- Women who have had multiple miscarriages due to chromosomal abnormalities
- Women who have had multiple failed IVF attempts with own eggs.
- Women who are menopausal.

Who Are Egg Donors at North Cyprus IVF?

Our egg donor base is consisted predominantly of international students studying at various universities in Cyprus. As a result, majority of our egg donors are between 20-24 years of age. This is precisely why our success rates are considerably higher than most of the IVF clinics in the world. Our egg donors are very young and most of them have previous positive donation histories.

In general, our egg donor selection criteria can be summarized as follows:
- women between 20-29 years of age.
- women with BMI's between 19-24
- women with no known hereditary genetic diseases in family.
- women with no mental disability
- women who do not use drugs and do not smoke

Our egg donors undergo a very strict screening process at our clinic before they are admitted to our donation program. All egg donors go through psychological counseling and numerous infectious disease testing as well as karyotype analysis.

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