Treatment Options

Going through a complete assessment of your personal fertility has a great importance on choosing the right treatment option since each treatment is suitable for a specific patient group regarding their fertility requirements.

Initial testing process is the first step infertility assessment. Detailed information where we describe some basics can be found in our "Infertility Testing and Interpretation of Test Results" section. Next, on the ; "Choosing the Right Treatment" section, you can come across some treatment suitable to some patient groups regarding factors such as; age, fertility assessment, previous obstetric history as well as history of fertility.

Together with the treatment, patient's lifestyle has also a great effect on the outcome of the treatment. Therefore, please do not forget to check our "Boost your Fertility".

Deciding on the clinic for your treatment might be challenging for you as you may have many choices around. However, be aware not to choose a clinic that is willing to proceed any treatment without a thorough evaluation of your personal needs. Please note that IVF is a personal, unique treatment and there isn't a single prescription applicable for everyone.

Some treatment options offered by the North Cyprus IVF Clinic is listed below. For more information, please do not hesitate to get in touch with us. We will be more than happy to assist you.

www.donasyon.net
www.lowcostivf.net
www.gender-selection-ivf.co.uk
www.egg-donor-ivf.co.uk

Azoospermia and Surgical Sperm Extraction Methods

One of the main factors of infertility is Azoospermia and has been estimated to effect 15% of all male infertility cases.

This factor which is in essence the complete absence of live sperm cells in the ejaculation can be split into two groups : obstructive azoospermia and non-obstructive azoospermia. The former suggests that there is a blockage along the sperm delivery system as where the latter suggests a problem in the production of sperm. 

The reasons behind this can be due to testicular failure but further investigation should be carried out by a urologist for a full diagnosis. 

We offer a few different options for treatment in such cases including : 

PESA - Percutaneous Epididymal Sperm Aspiration
MESA - Micro Epididymal Sperm Aspiration
TESE - Testicular Sperm Extraction

The diagram below shows how each of the surgical sperm retrieval methods are administered:

Please click on the link below for further detailed information
http://www.lowcostivf.net/tese-microtese-tesa-surgical-sperm-extraction.htm#.U0BlAlG1Zck


www.donasyon.net
www.lowcostivf.net
www.gender-selection-ivf.co.uk
www.egg-donor-ivf.co.uk

Sperm Donation

1- Who is a good candidate for sperm donation?
Patients with male factor infertility such as azoospermia or other sperm defects, or males with prior cancer treatment are potential candidates for sperm donor IVF treatment. Patients with genetic disorders that inhibit sperm production or patients with high risks of passing genetic disorders onto their children are also good candidates for sperm donation. Prior to sperm donation, we offer our patients the option of a surgical sperm retrieval option where sperm is retrieved surgically from within the testes to see if any live sperm cells can be found that may not make it to the ejaculate.

Single female patients who do not wish to seek treatment with a partner are also good candidates for our sperm donor IVF treatment program.
 

2- Who are your sperm donors?
The sperm we use come from an international sperm bank with their certificates. We only use certified sperm as certification process requires an extensive testing on the sperm to be repeated at certain intervals. This way, we can guarantee our patients that there are no testable defects on the sperm used in the IVF process.

3- What are your success rate with sperm donation?
Success rates with sperm donation tend to vary depending on the age and hormone profile of the female patient. If the female patient is young with a good hormone profile, then the success rates will be considerably high. However, women after 35 years of age tend to experience a decline in their fertility levels, therefore, the success rates tend to decline. For more information on our success rates, please view our 2011 success statistics page.

4- What is the cost of sperm donor IVF at North Cyprus IVF Clinic?
For a comprehensive cost information with alternative accommodation packages, please contact us using the contact form.
 

www.donasyon.net
www.lowcostivf.net
www.northcyprusivf.com
www.gender-selection-ivf.co.uk
www.egg-donor-ivf.co.uk

Sperm Retrieval

The usual way of producing sperm for use in Assisted Reproductive Technology is manual stimulation.  In cases where medical or religious factors prevent this, surgical methods can be used:

PESA
PESA (percutaneous epididymal sperm aspiration) is a method, performed under local anesthesia, which involves extracting sperm with a fine needle from the epididymis or testes.  The sperm is then implanted into the egg through the process of ICSI (Intracytoplasmic Sperm Injection) to be used in IVF.

TESA & TESE

In cases where the epididymis does not contain any sperm, because of impaired sperm production, the method of TESA (Testicular Sperm Aspiration) or TESE (Testicular Sperm Extraction) may be used.  TESE involves a surgical biopsy of the testis, while TESA is performed by sticking a needle into the testis and aspirating fluid and tissue with negative pressure.

MESA The most invasive of the surgical sperm retrieval procedures is MESA (micro-epididymal sperm aspiration), which is performed under general anesthesia. MESA involves the cutting open of the scrotum to retrieve sperm. The wound is closed with dissolvable stitches. Swelling and pain subsides within a few days, during which prescribed painkillers may be taken to ease the pain...

www.donasyon.net
www.lowcostivf.net
www.northcyprusivf.com
www.gender-selection-ivf.co.uk
www.egg-donor-ivf.co.uk

Infertility and IVF

At North Cyprus IVF Clinic, a thorough investigation is called for when making an assessment of your treatment options. It is important that the cause of infertility is mostly known when planning for treatment. 

When natural conception methods fail to produce pregnancy, IVF becomes an option. In vitro fertilization (IVF) is a process by which egg cells are fertilized by sperm outside the womb, in vitro. IVF is a major treatment in infertility when other methods of assisted reproductive technology have failed. The process involves hormonally controlling the ovulatory process, removing ova (eggs) from the woman's ovaries and letting sperm fertilize them in a fluid medium. The fertilized egg (zygote) is then transferred to the patient's uterus with the intent to establish a successful pregnancy. The first "test tube baby", Louise Brown, was born in 1978. Initially IVF was developed to overcome infertility due to problems of the fallopian tube, but it turned out that it was successful in many other infertility situations as well. The introduction of intracytoplasmic sperm injection (ICSI) addresses the problem of male infertility to a large extent. (Male infertility consists of failure to produce sperm.)

For IVF to be successful it may be easier to say that it requires healthy ova, sperm that can fertilize, and a uterus that can maintain a pregnancy. At North Cyprus IVF, before starting to plan your treatment, we make sure all of these conditions are met.

IVF can be used for females who have already gone through menopause. The donated oocyte from a healthy young woman can be fertilized in a crucible. If the fertilization is successful, the zygote will be transferred into the uterus, within which it will develop into an embryo.

Treatment cycles are typically started on the third day of menstruation and consist of a regimen of fertility medications to stimulate the development of multiple follicles of the ovaries. In most patients injectable gonadotropins (usually FSH analogues) are used under close monitoring. Such monitoring frequently checks the estradiol level and, by means of gynecologic ultrasonography, follicular growth. Typically approximately 10 days of injections will be necessary. Spontaneous ovulation during the cycle is typically prevented by the use of GnRH agonists or GnRH antagonists, which block the natural surge of luteinizing hormone (LH).

When follicular maturation is judged to be adequate, human chorionic gonadotropin (hCG) is given. This agent, which acts as an analogue of luteinizing hormone, would cause ovulation about 42 hours after injection, but a retrieval procedure takes place just prior to that, in order to recover the egg cells from the ovary. The eggs are retrieved from the patient using a transvaginal technique involving an ultrasound-guided needle piercing the vaginal wall to reach the ovaries. Through this needle follicles can be aspirated, and the follicular fluid is handed to the IVF laboratory to identify ova. It is common to remove between ten and thirty eggs. The retrieval procedure takes about 20 minutes and is usually done under conscious sedation or general anesthesia.

In the laboratory, the identified eggs are stripped of surrounding cells and prepared for fertilization. In the meantime, semen is prepared for fertilization by removing inactive cells and seminal fluid. If semen is being provided by a sperm donor, it will usually have been prepared for treatment before being frozen and quarantined, and it will be thawed ready for use. The sperm and the egg are incubated together at a ratio of about 75,000:1 in the culture media for about 18 hours. In most cases, the egg will be fertilized by that time and the fertilized egg will show two pronuclei. In certain situations, such as low sperm count or motility, a single sperm may be injected directly into the egg using intracytoplasmic sperm injection (ICSI). The fertilized egg is passed to a special growth medium and left for about 72 hours until the egg consists of eight cells.

Cytoplasmic Transfer

Cytoplasmic transfer is one of the latest innovations in IVF treatment. Even though cytoplasmic transfer in itself is not a treatment method, it is a procedure than can be used alongside with IVF. The main purpose of cytoplasmic transfer is to aid women who suffer from infertility due to deficient or damaged mitochondria, contained within an eggs cytoplasm.  Deficient mitochondria can lead to recurrent implantation failures and high levels of embryo fragmentation, which are causes of poor embryo development, and therefore,  a failed IVF cycle.  

Damage to mitochondria is often observed at higher ages, therefore, women in late 30s or early 40s are more prone to IVF failures due to compromised mitochondria. Cytoplasmic transfer uses the patient's own eggs but also requires a younger patient so that a healthy cytoplasm can be obtained for cytoplasmic transfer to take place. The younger patient's cytoplasm helps rejuvenate the patient's eggs and can increase the chances of success accordingly.

At North Cyprus IVF, we offer cytoplasmic transfer in order to give you a few more percentages of success. Make sure to ask us about our cytoplasmic transfer option to find out if you are suitable for this program.

www.donasyon.net
www.lowcostivf.net
www.northcyprusivf.com
www.gender-selection-ivf.co.uk
www.egg-donor-ivf.co.uk

Infertility Investigation

Infertility is often defined as inability to conceive naturally after trying for one year without any contraception. Women who are able to get pregnant but who are unable to carry pregnancy to full term are also considered to be infertile. About 10% of the US population, and around 9% of the European population between the ages of 15-44 have either difficulty conceiving or carrying pregnancy to full term.

Even though infertility is often perceived as a women's problem due to its direct link to pregnancy, female and male infertility have about the same level of prevalence within the society. About one-third of the causes of infertility are associated with female factor infertility and another one-third is associated with male factor infertility when the rest is either due to a combined male-female factor or unexplained infertility.

If you have been trying to get pregnant for the past one year and have not been able to get pregnant, then you might belong in either one of these groups. For partners who have not been successful at achieving pregnancy for a full year, a series of tests is in order. Infertility investigation works in a dual manner where both partners undergo a testing process. The starting point of infertility testing would be as follows:

- For male partner, a semen analysis is required. Krueger's semen analysis

provides information on sperm count, volume, motility, morphology and

a few more factors. This would be the starting point of infertility investigation.

- For female partner, hormone testing is in order. If the female partner has

regular menstrual periods, then hormone tests such as FSH, LH, Estradiol,

Prolactine and TSH. If the female partner is young, but does not have regular

menstrual periods, then apart from the hormone tests, further investigation

may be necessary to see into the ovarian function and the uterus. Irregular

periods could be due to Poly Cystic Ovarian Syndrome (PCOS) or any other

problems.

When standard hormone testing and sonogram investigations fail to provide an answer, more invasive testing process will be in order. Female partner might be required to have a hysteroscopy as well as certain infectious disease tests such as Chlamydia, CMV IgG and Toxoplasmosis.

When all the above testing processes fail to yield and answer, then thrombophilia defects and immune system problems are to be investigated. Especially for women with repeated miscarriages, thrombophilia is one of the main suspects.

Sometimes, patients who complete their first round of testing can be offered fertility treatment before attempting the more in-depth and invasive tests. This is simply because, the likelihood of belonging in the unexplained infertility group is very high and the expensive testing procedures can be very overwhelming. Therefore, before attempting these tests, an IVF treatment can be attempted first and if the result is negative, then further tests can be performed. In most cases, partners are able to achieve pregnancy without consulting the invasive testing processes.

At North Cyprus IVF, we take into consideration every single factor that can potentially be contributing to your infertility problems. When we ask you to have a series of tests, it is merely due to the fact that we are trying hard to make sure we are able to offer you the most effective type of treatment that is unique and suitable for your specific needs.

www.donasyon.net
www.lowcostivf.net
www.northcyprusivf.com
www.gender-selection-ivf.co.uk
www.egg-donor-ivf.co.uk

Male Infertility Problems

 Infertility in men is most often caused by:

1- Problems making sperm, which means producing too few sperm or none at all

2- Problems with the sperm's ability to reach the egg and fertilize it, which could be the case where abnormal sperm shape or structure prevent it from moving correctly

Sometimes a man is born with the problems that affect his sperm. Other times problems start later in life due to illness or injury. For example, cystic fibrosis often causes infertility in men. The number and quality of a man's sperm can also be affected by his overall health and lifestyle. Some things that may reduce sperm number and/or quality include:

- alcohol

- drugs

- environmental toxins, including pesticides and lead

- smoking cigarettes

- health problems

- medicines

-radiation treatment and chemotherapy for cancer

-age

In some cases, even if sperm production is not sufficient enough to produce sperm through ejaculation, minor surgical procedures like TESA and MESA can be used to retrieve the sperm. In the cases where the sperm is unable to reach and fertilize the egg, ICSI is used for assisted fertilization. In other cases where no sperm can be found or the quality is exceptionally low, using donor sperm becomes the only alternative.

Semen Analysis

With the aid of a semen analysis, sperm can  be categorized in the following groups:

Azoospermia: Nearly or no live sperm cells in semen

Oligospermia: Low count of live sperm cells

Asthenospermia: Low motility

Terathospermia: Low morphology

Fertile: No problems with count, motility or morphology

Sub-Fertile: Slight male factor infertility.

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www.northcyprusivf.com 
www.gender-selection-ivf.co.uk 
www.egg-donor-ivf.co.uk

2011's Last Bundles of Joy!

The Truth About our Egg Donors

Over the last few months it has come to our attention that there has been some controversy over our egg donor lists and available donors.

First and foremost, it is important to note that if there are women who are planning to cycle around the same time and their physical characteristics are similar, they will be offered the same list of donors. Depending on the recipient that chooses first, the donor is then assigned to that individual and the women who have been offered the same donors are notified.

It is very difficult for our team to provide donors 2-3 months in advance for the fact that at any given point in time, a donor can decide to stop with the treatment and  egg donation. If this happens then the recipient is left hanging and the cycle needs to be abandoned.

Our preferred way to deal with our egg donation patients and their donors is to coordinate and synchronize them shortly before the recipient menstrual cycle starts.

We also ask that you send a photo of yourself along with the application form so we can do our best to find the best match for you.

We are aware that this may seem  last minute however it is the best and most accurate way to get the closest donor match.

There are times when frozen eggs are used however the patient is fully aware and accepting of this. We do not do shared cycles unless it is discussed and agreed in advance.

As there are many accredited Universities in Northern Cyprus, there are many young women who are enrolling to donate, donating and cycling on a regular basis.

One of the most important factors when choosing a clinic for your Egg Donation Treatment is TRUST, especially with anonymous donation.

North Cyprus IVF Center is ISO 9001 Certified which means we are constantly reviewed and evaluated to make sure that International Standards are met.

Dr. Savas Ozyigit and our team pride ourselves on working ethically towards a common goal which is to help you conceive.

Please do not hesitate to contact us if you have any questions, comment or concerns.

We also have past patients who would be happy to act as a reference and share their experiences with you.

www.donasyon.net
www.lowcostivf.net
www.northcyprusivf.com
www.gender-selection-ivf.co.uk
www.egg-donor-ivf.co.uk

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